Michael Keane missed yesterday's defeat at Leicester after developing an infection in the foot that was cut open five weeks ago.
The defender, a £30m acquisition from Burnley over the summer, didn't travel with the Everton squad to the King Power Stadium and caretaker manager David Unsworth explained after the game that Keane had to be hospitalised to treat the problem.
Keane suffered a gash to his foot in the League Cup Third Round win over Sunderland on 20th September and missed the next two games but returned to face his old club at the start of the month.
He has battled to keep the wound closed, however, and it became infected, spreading up his leg and requiring more intensive treatment.
Keane will be discharged from hospital today but it is unclear when he will be ready to play again.
The 24-year-old was joined on the injured list again by James McCarthy who has sustained what Unsworth describes as a “slight” hamstring strain. He is scheduled to be out for a couple of weeks but may be forced to miss Ireland's upcoming World Cup qualifying playoff game.
The situation around Nikola Vlasic is less clear, however. The Croatian missed the midweek cup trip to Chelsea after being stamped on his foot during the defeat to Arsenal in the Premier League the Sunday before.
It was assumed that his failure to travel with the team to Leicester was because he was still carrying the knock despite a scan turning up no damage but his sister, Blanka, insisted on Twitter that her brother was fully fit and available but wasn't selected.
Furthermore, if a quote supposedly attributed to him in Hrvatske Novine in Croatia is true, he might not be settled with the Blues just weeks after signing from Hajduk Split for £10m.
“The move has been positive but my agent will sit with me before January and see where we stand,” the 19-year-old is supposed to have said.
Vlasic was one of the best performers under Ronald Koeman before the Dutchman's sacking and it was assumed that he would be an important member of the team this season as Everton attempt to drag themselves out of trouble at the bottom of the table.