The Stoke City goalkeeper, himself looking forward to getting a start in place of Joe Hart, broke a finger at the St George's Park training camp and is ruled out of the friendly with Germany.
With manager Gareth Southgate keen to run the rule over his fringe players this international break, that meant an appearance for Pickford who has impressed at Everton since joining the Blues from Sunderland over the summer.
The 23-year-old made some key saves, particularly early on, to keep the Germans at bay and help in earning a goalless draw.
Pickford could be joined in the England team by fellow Blue Dominic Calvert-Lewin for the upcoming match against Brazil, too.
Calvert-Lewin looks set to be promoted from the Under-21s following yet another injury in Southgate's squad.